Invitrogen™ Laminin gamma-1 Recombinant Rabbit Monoclonal Antibody (7B2C2)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
MA558203	Invitrogen™ MA558203	20 μL
MA558204	Invitrogen™ MA558204	100 μL

Description

Immunogen sequence: ECPACYRLVK DKVADHRVKL QELESLIANL GTGDEMVTDQ AFEDRLKEAE REVMDLLREA QDVKDVDQNL MDRLQRVNNT LSSQISRLQN IRNTIEETGN LAEQARAHVE NTERLIEIAS RELEKAKVAA ANVSVTQPES TGDPNNMTLL AEEARKLAER HKQEADDIVR VAKTANDTST EAYNLLLRTL AGENQTAFEI EELNRKYEQA KNISQDLEKQ AARVHEEAKR AGDKAVEIYA SVAQLS.

Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of alpha, beta and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.

Specifications

• Antigen: Laminin gamma-1
• Concentration: 0.22 mg/mL
• Applications: ELISA, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P02468
• Gene ID (Entrez): 117036, 226519
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1275 of human LAMC1 (NP_002284.3).
• Product Type: Antibody

• Clone: 7B2C2
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Mouse, Rat
• Gene: LAMC1
• Gene Alias: AA408497; B2e; basement membrane protein; LAMA; LAMA1; Lama-1; LAMB2; LAMC1; Laminin A chain; laminin B2 chain; laminin gamma 1 chain; laminin S; laminin subunit alpha 1; laminin subunit alpha-1; laminin subunit gamma 1; laminin subunit gamma-1; laminin, alpha 1; laminin, beta 2; laminin, gamma 1; laminin, gamma 1 (formerly LAMB2); laminin-1; laminin-1 subunit alpha; Laminin-1 subunit gamma; laminin-10 subunit gamma; Laminin-11 subunit gamma; laminin-2 subunit gamma; Laminin-3 subunit alpha; laminin-3 subunit gamma; Laminin-4 subunit gamma; laminin-6 subunit gamma; Laminin-7 subunit gamma; laminin-8 subunit gamma; Laminin-9 subunit gamma; PTBHS; S-LAM alpha; S-LAM gamma; S-LAM-alpha; S-laminin subunit alpha; S-laminin subunit gamma
• Gene Symbols: LAMC1
• Primary or Secondary: Primary
• Purification Method: Protein A