Invitrogen™ Laminin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143613

Catalog No. PIPA5143613

Description

Laminin Polyclonal Antibody for Western Blot, ICC/IF, IHC (PFA)

Laminin is a crucial glycoprotein that plays a significant role in the extracellular matrix, particularly within the basement membrane. It is composed of three subunits: alpha, beta, and gamma chains. These chains are disulfide-linked polypeptides that together form a heterotrimer, resembling the shape of a cross. The human genome encodes 11 genetically distinct laminin chains, which combine to form over 14 different laminin isoforms, each with specific tissue distributions and functions. Laminins can bind to other laminin molecules, as well as integrins and other matrix proteins, providing structural support and influencing cell differentiation, migration, and adhesion. These glycoproteins are vital during early embryonic development, where they contribute to the formation of basement membrane-like structures, even in the absence of type IV collagen. The evolutionary origin of laminin gene families can be traced back to early branching animals, providing insights into metazoan gene family development.

Specifications

• Antigen: Laminin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LAMC1
• Gene Alias: 5830440B04; AA408497; B2e; basement membrane protein; C77966; C80098; C81607; CLM; D130003D08Rik; dy; dystrophia muscularis; LAMA; LAMA1; Lama-1; Lama2; LAMB1; Lamb-1; LAMB1; basement membrane protein; Lamb1-1; Lamb2; LAMC1; Laminin A chain; laminin alpha 2 subunit; laminin B1; laminin B1 chain; laminin B1 subunit 1; laminin B2 chain; laminin beta-1 chain; laminin gamma 1 chain; laminin M chain; laminin S; laminin subunit alpha 1; laminin subunit alpha 2; laminin subunit alpha-1; Laminin subunit alpha-2; laminin subunit beta 1; laminin subunit beta-1; laminin subunit gamma 1; laminin subunit gamma-1; laminin, alpha 1; laminin, alpha 2; laminin, beta 1; laminin, beta 2; laminin, gamma 1; laminin, gamma 1 (formerly LAMB2); laminin-1; laminin-1 subunit alpha; Laminin-1 subunit beta; laminin-1 subunit gamma; Laminin-10 subunit beta; laminin-10 subunit gamma; Laminin-11 subunit gamma; laminin-12 subunit alpha; Laminin-12 subunit beta; laminin-2 subunit alpha; Laminin-2 subunit beta; laminin-2 subunit gamma; Laminin-3 subunit alpha; laminin-3 subunit gamma; Laminin-4 subunit alpha; laminin-4 subunit gamma; Laminin-6 subunit beta; laminin-6 subunit gamma; Laminin-7 subunit gamma; laminin-8 subunit beta; Laminin-8 subunit gamma; laminin-9 subunit gamma; LAMM; LIS5; LOW QUALITY PROTEIN: laminin subunit alpha-1; LOW QUALITY PROTEIN: laminin subunit alpha-2; LOW QUALITY PROTEIN: laminin subunit beta-1; mer; merosin; merosin heavy chain; mKIAA4087; PTBHS; S-LAM alpha; S-LAM gamma; S-LAM-alpha; S-laminin subunit alpha; S-laminin subunit gamma
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117036, 16772, 16773, 16777, 226519, 284217, 298941, 309368, 316758, 3908, 3912, 3915
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 5mM sodium azide
• Gene Accession No.: P02468, P02469, P07942, P11047, P19137, P24043, P25391, Q60675
• Gene Symbols: LAMA1, LAMA2, LAMB1, LAMC1
• Immunogen: Laminin 111 from mouse EHS sarcoma cells obtained from Sigma-Aldrich,.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG