Invitrogen™ LAMTOR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551792

Catalog No. PIPA551792

Description

Immunogen sequence: NEDSDQDREE RKLLLDPSSP PTKALNGAEP NYHSLPSART DEQALLSSIL AKTASNIIDV SAADSQGMEQ HEYMDRARQY STRLAVLSSS LTHWKKLPPL PSLTSQPHQV LASEPIPFSD LQQVSRIAAY AYSALSQIRV DAKEELVV Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 97%.

The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.

Specifications

• Antigen: LAMTOR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LAMTOR1
• Gene Alias: 2400001E08Rik; C11orf59; Lamtor1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; lipid raft adaptor protein p18; p18; p27kip1 releasing factor from RhoA; p27Kip1-releasing factor from RhoA; p27RF Rho; p27RF-Rho; Pdro; PP7157; Protein associated with DRMs and endosomes; ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59; RhoA activator C11orf59 homolog
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55004
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6IAA8
• Gene Symbols: LAMTOR1
• Immunogen: Recombinant protein corresponding to Human LAMTOR1. Recombinant protein control fragment (Product #RP-95926).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG