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Invitrogen™ LAP2 Monoclonal Antibody (3A3)
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Catalog No. PIMA536300
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100 μL
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Catalog No. Quantity
PIMA536300 100 μL
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Catalog No. PIMA536300 Supplier Invitrogen™ Supplier No. MA536300
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Description

Mouse Monoclonal Antibody

Western blot detects a band of approximately 77 kDa (predicted molecular weight: 75 kDa).

In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B and 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A/B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LAP2
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3A3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene TMPO
Gene Accession No. P42166
Gene Alias 5630400D24Rik; AI195756; AI606875; AW214352; AW547477; CMD1T; lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoform alpha; Lamina-associated polypeptide 2, isoform beta; Lamina-associated polypeptide 2, isoforms alpha/zeta; Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma; Lamina-associated polypeptide 2, isoforms beta/gamma; Lap2; LEM domain containing 4; LEMD4; PRO0868; Splenin; Thymopentin; Thymopoietin; Thymopoietin (lamina associated polypeptide 2); thymopoietin beta; Thymopoietin isoform alpha; Thymopoietin isoform beta; Thymopoietin isoforms alpha/zeta; Thymopoietin isoforms beta/delta/epsilon/gamma; Thymopoietin, isoforms beta/gamma; Thymopoietin-related peptide isoform alpha; thymopoietin-related peptide isoforms beta/gamma; TMPO; TP; TP alpha; TP alpha/zeta; TP beta; TP beta/delta/epsilon/gamma; TP beta/gamma; TP5; TPRP isoform alpha; TPRP isoforms beta/gamma
Gene Symbols TMPO
Host Species Mouse
Immunogen Antibody was raised against amino acids 684-694 corresponding to the C-terminus of human LAP2.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7112
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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