Invitrogen™ LAP2 Monoclonal Antibody (6E10)

Catalog No.	Quantity
PIMA125323	100 μL

Catalog No. PIMA125323 Supplier Invitrogen™ Supplier No. MA125323

Description

Mouse Monoclonal Antibody

Recommended positive controls: K562. MA1-25323 is expected to cross react with mouse (100% conserved), rat (100% conserved), Xenopus laevis (90% conserved), and bovine (88% conserved) due to sequence homology.

In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B and 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A/B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.

Specifications

• Antigen: LAP2
• Applications: ChIP Assay, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 6E10
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene: TMPO
• Gene Accession No.: P42166
• Gene Alias: 5630400D24Rik; AI195756; AI606875; AW214352; AW547477; CMD1T; lamina-associated polypeptide 2; Lamina-associated polypeptide 2, isoform alpha; Lamina-associated polypeptide 2, isoform beta; Lamina-associated polypeptide 2, isoforms alpha/zeta; Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma; Lamina-associated polypeptide 2, isoforms beta/gamma; Lap2; LEM domain containing 4; LEMD4; PRO0868; Splenin; Thymopentin; Thymopoietin; Thymopoietin (lamina associated polypeptide 2); thymopoietin beta; Thymopoietin isoform alpha; Thymopoietin isoform beta; Thymopoietin isoforms alpha/zeta; Thymopoietin isoforms beta/delta/epsilon/gamma; Thymopoietin, isoforms beta/gamma; Thymopoietin-related peptide isoform alpha; thymopoietin-related peptide isoforms beta/gamma; TMPO; TP; TP alpha; TP alpha/zeta; TP beta; TP beta/delta/epsilon/gamma; TP beta/gamma; TP5; TPRP isoform alpha; TPRP isoforms beta/gamma
• Gene Symbols: TMPO
• Host Species: Mouse
• Immunogen: Synthetic peptide corresponding to amino acids 29-50 common to the N-terminus of all human TMPOs (isoforms alpha, beta, gamma, delta, epsilon, and zeta).
• Purification Method: Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7112
• Target Species: Human, X. laevis
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1