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Tocris Bioscience™ Lapatinib

Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor (IC50 values are 9.8 and 10.2 nM, respectively)

Manufacturer:  Tocris Bioscience™ 6811/10

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Catalog No. 68-111-0


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Description

Description

Lapatinib is a potent and selective dual ErbB2 (HER-2) and EGFR inhibitor (IC50 values are 9.8 and 10.2 nM, respectively). Selective for EGFR and ErbB-2 versus other proliferative kinases. Inhibits proliferation in multiple cancer cell lines (average IC50 values <0.16 μM). Exhibits 100-fold average selectivity for the tumor cells versus human foreskin fibroblasts. Inhibits EGFR/ErbB2 autophosphorylation and phosphorylation of the downstream modulator AKT.
Specifications

Specifications

C29H26ClFN4O4S
581.06
231277-92-2
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-4-quinazolinamine
98%
10 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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