Invitrogen™ LAR4B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557721

Catalog No. PIPA557721

Description

Immunogen sequence: FENRLSSLII GPSKERTLSA DASVNTLPVV VSREPSVPAS CAVSATYERS PSPAHLPDDP KVAEKQRETH SVDRLPSALT ATACKSVQVN Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.

The LAR4B gene, more accurately referred to as LARP4B (La Ribonucleoprotein Domain Family Member 4B), is associated with RNA-binding proteins that are crucial for various aspects of RNA metabolism, including RNA stabilization, translation, and cellular stress responses. LARP4B belongs to the La-related protein family, which plays significant roles in maintaining RNA stability and enhancing translation efficiency of certain mRNAs. It has been identified as a target in cancer research due to its involvement in tumor biology, particularly regulating tumor suppressive pathways and interacting with microRNA networks. Studies have shown that LARP4B expression is downregulated in prostate cancer tissues, indicating its potential role as a tumor suppressor. Moreover, it is linked with liver cancer and survival rates, reflecting its importance in cellular growth and proliferation. The regulation of LARP4B and its interactions with other cellular components underline its potential therapeutic implications for cancer treatment.

Specifications

• Antigen: LAR4B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LARP4B
• Gene Alias: A630096F19; AI256361; D13Wsu64e; KIAA0217; La ribonucleoprotein 4B; La ribonucleoprotein domain family member 4B; La ribonucleoprotein domain family member 5; La ribonucleoprotein domain family, member 4B; La ribonucleoprotein domain family, member 5; la-related protein 4B; La-related protein 5; LARP4B; Larp5; RGD1310713
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23185
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q92615
• Gene Symbols: LARP4B
• Immunogen: Recombinant protein corresponding to Human LAR4B. Recombinant protein control fragment (Product #RP-97042).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov