Tocris Bioscience™ Laropiprant

Description

Potent and selective prostaglandin D2 receptor antagonist

Laropiprant is a potent and selective prostaglandin D2 receptor antagonist (IC50 = 0.09 nM in washed platelets; Ki = 0.57). It exhibits selectivity for binding to PGD2 receptors over other prostanoid receptors (Ki values are ≥ 2.95 nM for TP, EP1, EP2, EP3, EP4, FP and IP). Laropiprant promotes coagulation of whole blood ex vivo and reduces bleeding time in mice in vivo. In a mouse model of intracerebral hemorrhage, Laropiprant reduces lesion volume and attenuates neurological deficit scores. The compound also reduces Niacin (Cat. No. 4106) induced vasodilation.

Specifications

• Chemical Name or Material: (3 R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid
• CAS: 571170-77-9
• Quantity: 50 mg
• Target: Prostanoid Receptor Antagonists
• Molecular Formula: C₂₁H₁₉ClFNO₄S
• Purity: 0.98