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Invitrogen™ Lass5 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA595900
Description
Immunogen sequence: MMKPRPKRFI AKPCALCIGI EDSGPYQAQP NAILEKVFIS ITKYPDKKRL EGLSKQLDWN VRKIQCWFRH RRNQDKPPTL TKFCESMWRF TFYLCIFCYG.
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.
Specifications
Lass5 | |
Polyclonal | |
Unconjugated | |
CERS5 | |
2310081H14Rik; AU045339; AW544927; Ceramide synthase 5; CerS5; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5; LASS5; longevity assurance homolog 5; Sphingosine N-acyltransferase CERS5; TRAM homolog 4; translocating chain-associating membrane protein homolog 4; Trh4 | |
Rabbit | |
Affinity chromatography | |
RUO | |
91012 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
ELISA, Western Blot | |
1.11 mg/mL | |
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3 | |
Q8N5B7 | |
CERS5 | |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CERS5 (NP_0012686601). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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