Invitrogen™ Lass5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520570

Catalog No. PIPA520570

Description

A suggested positive control is rat brain tissue lysate. PA5-20570 can be used with blocking peptide PEP-0690.

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.

Specifications

• Antigen: Lass5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CERS5
• Gene Alias: 2310081H14Rik; AU045339; AW544927; Ceramide synthase 5; CerS5; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5; LASS5; longevity assurance homolog 5; Sphingosine N-acyltransferase CERS5; TRAM homolog 4; translocating chain-associating membrane protein homolog 4; Trh4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 366984, 71949, 91012
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8N5B7, Q9D6K9
• Gene Symbols: CERS5
• Immunogen: An 18 amino acid peptide near the amino terminus of the human LASS5.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG