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LASS5 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986319
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50-198-6319 100 μL
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Catalog No. 50-198-6319 Supplier Bioss Supplier No. BS5082R
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Description

Rabbit Polyclonal Antibody

The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.

Specifications

Antigen LASS5
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene CERS5
Gene Accession No. Q8N5B7
Gene Alias 2310081H14Rik; AU045339; AW544927; Ceramide synthase 5; Cers5; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5; LASS5; longevity assurance homolog 5; Sphingosine N-acyltransferase CERS5; TRAM homolog 4; Translocating chain-associating membrane protein homolog 4; Trh4
Gene Symbols CERS5
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human LASS5.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91012
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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