LASS5 Rabbit anti-Human, Polyclonal, Bioss
Rabbit Polyclonal Antibody
Manufacturer: Bioss BS5082R
DescriptionThe LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis.
|Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH|
|2310081H14Rik; AU045339; AW544927; Ceramide synthase 5; Cers5; LAG1 homolog, ceramide synthase 5; LAG1 longevity assurance homolog 5; LASS5; longevity assurance homolog 5; Sphingosine N-acyltransferase CERS5; TRAM homolog 4; Translocating chain-associating membrane protein homolog 4; Trh4|
|KLH conjugated synthetic peptide derived from human LASS5.|
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