Invitrogen™ Lass6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566591

Catalog No. PIPA566591

Description

Immunogen sequence: WLPHNVTWADL KNTEEATFPQ AEDL Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.

Specifications

• Antigen: Lass6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CERS6
• Gene Alias: 4732462C07Rik; AW544719; Ceramide synthase 6; CERS5; CerS6; LAG1 homolog, ceramide synthase 6; LAG1 longevity assurance homolog 6; LASS6; longevity assurance homolog 6; MGC129949; MGC129950; RGD1561599; T1L
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 253782
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6ZMG9
• Gene Symbols: CERS6
• Immunogen: Recombinant Human Lass6. Recombinant protein control fragment (Product #RP-107244).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG