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Invitrogen™ LAT Polyclonal Antibody
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Catalog No. PIPA5120935
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100 μL
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PIPA5120935 100 μL
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Catalog No. PIPA5120935 Supplier Invitrogen™ Supplier No. PA5120935
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Description

Rabbit Polyclonal Antibody

Positive test controls include: THP-1. The target is usually found in the following locations: Cell membrane, Single-pass type III membrane protein. Immunogen sequence: PSSRRDSDGA NSVASYENEG ASGIRGAQAG WGVWGPSWTR LTPVSLPPEP ACEDADEDED DYHNPGYLVV LPDSTPATST AAPSAPALST PGIRDSAFSM ESIDDYVNVP ESGESAEASL DGSREYVNVS QELHPGAAKT EPAALSSQEA EEVEEEGAPD YENLQELN.

LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LAT
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.48 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene LAT
Gene Accession No. O43561
Gene Alias 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; Lat; LAT1; linker for activation of T cells; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells; linker for activation of T-cells family member 1; linker protein; p36-38; pp36
Gene Symbols LAT
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 95-262 of human LAT (NP_055202.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27040
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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