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Invitrogen™ Latexin Monoclonal Antibody (02)
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Catalog No. PIMA529404
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100 μL
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Catalog No. Quantity
PIMA529404 100 μL
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Catalog No. PIMA529404 Supplier Invitrogen™ Supplier No. MA529404
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Description

Mouse Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human Latexin/Lxn.

Latexin, also known as LXN, is a carboxypeptidase A inhibitor found in mammals, and it shares structural similarities with cystatin C, suggesting its role in protein abundance regulation. The LXN gene is located on chromosome 3, specifically at 3q25.32, encompassing 5 exons and coding for a protein of 222 amino acids. Latexin is identified as a molecular marker in the developing rat brain and is known for its tumor suppressive activities. With a molecular weight of 29 kDa, LXN is highly expressed in macrophages and plays a significant role in the inflammatory immune response, including regulating macrophage polarity and enhancing tumor immune surveillance. Research involving a Lxn knockout mouse model has demonstrated its importance in the regulation of hematopoietic stem cell function, suggesting its involvement in cellular homeostasis and survival mechanisms. Additionally, latexin contributes to sex dimorphism in hematopoiesis through gender-specific differential expression of microRNA, indicating its nuanced role in genetic regulation and cellular processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Latexin
Applications Flow Cytometry
Classification Monoclonal
Clone 02
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene LXN
Gene Accession No. Q9BS40
Gene Alias ECI; endogenous carboxypeptidase inhibitor; Latexin; latexin protein; Lxn; MUM; Protein MUM; TCI; tissue carboxypeptidase inhibitor
Gene Symbols LXN
Host Species Mouse
Immunogen Recombinant Human Latexin protein (Glu2-Glu222).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56925
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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