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Invitrogen™ Latexin Polyclonal Antibody
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Catalog No. PIPA523253
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100 μg
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PIPA523253 100 μg
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Catalog No. PIPA523253 Supplier Invitrogen™ Supplier No. PA523253
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Description

Rabbit Polyclonal Antibody

Latexin Polyclonal Antibody for Western Blot, IHC (P), Flow

Latexin, also known as LXN, is a carboxypeptidase A inhibitor found in mammals, and it shares structural similarities with cystatin C, suggesting its role in protein abundance regulation. The LXN gene is located on chromosome 3, specifically at 3q25.32, encompassing 5 exons and coding for a protein of 222 amino acids. Latexin is identified as a molecular marker in the developing rat brain and is known for its tumor suppressive activities. With a molecular weight of 29 kDa, LXN is highly expressed in macrophages and plays a significant role in the inflammatory immune response, including regulating macrophage polarity and enhancing tumor immune surveillance. Research involving a Lxn knockout mouse model has demonstrated its importance in the regulation of hematopoietic stem cell function, suggesting its involvement in cellular homeostasis and survival mechanisms. Additionally, latexin contributes to sex dimorphism in hematopoiesis through gender-specific differential expression of microRNA, indicating its nuanced role in genetic regulation and cellular processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Latexin
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.05% sodium azide
Gene LXN
Gene Accession No. P70202, Q64361, Q9BS40
Gene Alias ECI; endogenous carboxypeptidase inhibitor; Latexin; latexin protein; Lxn; MUM; Protein MUM; TCI; tissue carboxypeptidase inhibitor
Gene Symbols LXN
Host Species Rabbit
Immunogen A portion of amino acids 200-222 of human Latexin.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17035, 56925, 59073, 781644
Target Species Human, Mouse, Rat, Bovine
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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