Invitrogen™ Latexin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA528534

Catalog No. PIPA528534

Description

Recommended positive controls: 293T, HeLaS3, Molt-4, mouse brain, rat brain, , rat heart. Predicted reactivity: Mouse (85%), Rat (85%), Rhesus Monkey (97%), Bovine (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Latexin, also known as LXN, is a carboxypeptidase A inhibitor found in mammals, and it shares structural similarities with cystatin C, suggesting its role in protein abundance regulation. The LXN gene is located on chromosome 3, specifically at 3q25.32, encompassing 5 exons and coding for a protein of 222 amino acids. Latexin is identified as a molecular marker in the developing rat brain and is known for its tumor suppressive activities. With a molecular weight of 29 kDa, LXN is highly expressed in macrophages and plays a significant role in the inflammatory immune response, including regulating macrophage polarity and enhancing tumor immune surveillance. Research involving a Lxn knockout mouse model has demonstrated its importance in the regulation of hematopoietic stem cell function, suggesting its involvement in cellular homeostasis and survival mechanisms. Additionally, latexin contributes to sex dimorphism in hematopoiesis through gender-specific differential expression of microRNA, indicating its nuanced role in genetic regulation and cellular processes.

Specifications

• Antigen: Latexin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LXN
• Gene Alias: ECI; endogenous carboxypeptidase inhibitor; Latexin; latexin protein; Lxn; MUM; Protein MUM; TCI; tissue carboxypeptidase inhibitor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17035, 56925, 59073
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P70202, Q64361, Q9BS40
• Gene Symbols: LXN
• Immunogen: Recombinant protein encompassing a sequence within the center region of human LXN. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG