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Invitrogen™ Latexin Recombinant Rabbit Monoclonal Antibody (009)
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Catalog No. PIMA531047
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PIMA531047 100 μL
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Catalog No. PIMA531047 Supplier Invitrogen™ Supplier No. MA531047
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Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Mouse Latexin/LXN.

Latexin, also known as LXN, is a carboxypeptidase A inhibitor found in mammals, and it shares structural similarities with cystatin C, suggesting its role in protein abundance regulation. The LXN gene is located on chromosome 3, specifically at 3q25.32, encompassing 5 exons and coding for a protein of 222 amino acids. Latexin is identified as a molecular marker in the developing rat brain and is known for its tumor suppressive activities. With a molecular weight of 29 kDa, LXN is highly expressed in macrophages and plays a significant role in the inflammatory immune response, including regulating macrophage polarity and enhancing tumor immune surveillance. Research involving a Lxn knockout mouse model has demonstrated its importance in the regulation of hematopoietic stem cell function, suggesting its involvement in cellular homeostasis and survival mechanisms. Additionally, latexin contributes to sex dimorphism in hematopoiesis through gender-specific differential expression of microRNA, indicating its nuanced role in genetic regulation and cellular processes.
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Specifications

Antigen Latexin
Applications ELISA
Classification Recombinant Monoclonal
Clone 009
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene LXN
Gene Accession No. P70202
Gene Alias ECI; endogenous carboxypeptidase inhibitor; Latexin; latexin protein; Lxn; MUM; Protein MUM; TCI; tissue carboxypeptidase inhibitor
Gene Symbols LXN
Host Species Rabbit
Immunogen Recombinant Mouse Latexin/LXN protein (Glu2-Glu222).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17035
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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