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LATS1/2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985885
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100 μL
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50-198-5885 100 μL
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Catalog No. 50-198-5885 Supplier Bioss Supplier No. BS4081R
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Description

Rabbit Polyclonal Antibody

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Specifications

Antigen LATS1/2
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene LATS1
Gene Accession No. O95835
Gene Alias AW208599; h-warts; large tumor suppressor; Large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; Lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Gene Symbols LATS1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human LATS2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9113
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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