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Invitrogen™ LATS1 Polyclonal Antibody
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Catalog No. PIPA578278
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100 μL
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PIPA578278 100 μL
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Catalog No. PIPA578278 Supplier Invitrogen™ Supplier No. PA578278
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Description

Rabbit Polyclonal Antibody

Positive Control: 293T, A431, HeLa, HepG2, U87-MG, SK-N-SH, IMR32, SK-N-AS Predicted Reactivity: Mouse (90%), Rat (92%), Dog (90%), Sheep (90%), Bovine (90%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LATS1
Applications Western Blot
Classification Polyclonal
Concentration 0.67 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene LATS1
Gene Accession No. O95835
Gene Alias AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Gene Symbols LATS1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the N-terminus region of human LATS1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9113
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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