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Invitrogen™ LATS1 Polyclonal Antibody
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Catalog No. PIPA583209
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100 μL
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PIPA583209 100 μL
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Catalog No. PIPA583209 Supplier Invitrogen™ Supplier No. PA583209
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PSWEPNSQTK RYSGNMEYVI SRISPVPPGA WQEGYPPPPL NTSPMNPPNQ GQRGISSVPV GRQPIIMQSS SKFNFPSGRP Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 96%.

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LATS1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene LATS1
Gene Accession No. O95835
Gene Alias AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Gene Symbols LATS1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LATS1. Recombinant protein control fragment (Product #RP-96529).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9113
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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