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Invitrogen™ LATS1 Recombinant Rabbit Monoclonal Antibody (2H43L6)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ 702117
Description
This antibody is predicted to react with Monkey, Horse, Bovine, Sheep Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Specifications
LATS1 | |
Recombinant Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
O95835 | |
LATS1 | |
Protein corresponding to human LATS1 (aa11-277). | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
Western Blot | |
2H43L6 | |
Unconjugated | |
LATS1 | |
AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts | |
Rabbit | |
Protein A | |
RUO | |
9113 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
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