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Invitrogen™ LATS1 Recombinant Rabbit Monoclonal Antibody (5I10Q5)
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Catalog No. FEMA551398
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100 μL
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FEMA551398 100 μL
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Catalog No. FEMA551398 Supplier Invitrogen™ Supplier No. MA551398
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Rabbit Recombinant Monoclonal Antibody

LATS1 Recombinant Monoclonal Antibody for ELISA, Western Blot

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LATS1
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 5I10Q5
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.09% sodium azide; pH 7.3
Gene LATS1
Gene Accession No. O95835
Gene Alias AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Gene Symbols LATS1
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9113
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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