Invitrogen™ LATS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120433

Catalog No. PIPA5120433

Description

Positive test controls include: Mouse testis, Rat lung, Rat testis, Rat kidney. The target is usually found in the following locations: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle pole. Immunogen sequence: FGPYQKALRE IRYSLLPFAN ESGTSAAAEV NRQMLQELVN AGCDQEMAGR ALKQTGSRSI EAALEYISKM GYLDPR.

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity. LATS2 plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.

Specifications

• Antigen: LATS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LATS2
• Gene Alias: 4932411G09Rik; AV277261; AW228608; h-warts; Kinase phosphorylated during mitosis protein; KPM; large tumor suppressor 2; large tumor suppressor homolog 2; large tumor suppressor kinase 2; large tumor suppressor, homolog 2; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2; LATS2; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2; si:ch211-173o4.2; Warts-like kinase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26524, 305922, 50523
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.46 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q7TSJ6, Q9NRM7
• Gene Symbols: LATS2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 70-145 of human LATS2 (NP_0553872).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG