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LATS2 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA583944
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100 μL
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PIPA583944 100 μL
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Catalog No. PIPA583944 Supplier Thermo Scientific Supplier No. PA583944

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ALEYISKMGY LDPRNEQIVR VIKQTSPGKG LMPTPVTRRP SFEGTGDSFA SYHQLSGTPY EGPSFGADGP TALEEMPRPY VDYLFPGVGP HGPGHQHQHP PKGYGASVEA AGAHFPL

LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity. LATS2 plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LATS2
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide, pH 7.2
Gene LATS2
Gene Accession No. Q9NRM7
Gene Alias 4932411G09Rik, AV277261, AW228608, h-warts, Kinase phosphorylated during mitosis protein, KPM, large tumor suppressor 2, large tumor suppressor homolog 2, large tumor suppressor kinase 2, large tumor suppressor, homolog 2, LATS (large tumor suppressor, Drosophila) homolog 2, LATS, large tumor suppressor, homolog 2, LATS2, serine/threonine kinase KPM, serine/threonine-protein kinase kpm, Serine/threonine-protein kinase LATS2, si:ch211-173o4.2, Warts-like kinase
Gene Symbols LATS2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LATS2
Purification Method Anitgen affinity chromatography, Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26524
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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