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LATS2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 202761AP150UL

Encompass_Preferred

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Catalog No. 50-553-337


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Description

Description

LATS2 has a calculated molecular mass of 120 kDa and an apparent molecular mass of 150 kDa. The antibody is specific to LATS2.

LATS2 is a serine/threonine kinase that serves as a negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. LATS2 acts as a tumor supressor which plays a critical role in centrosome duplication, maintece of mitotic fidelity and genomic stability. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.
Specifications

Specifications

LATS2
Polyclonal
Unconjugated
LATS2
KPM, LATS2, Warts like kinase
Rabbit
Antigen Affinity Chromatography
RUO
26524, 50523
-20°C
Liquid
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.27 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q7TSJ6, Q9NRM7
Lats2
Peptide
150 μL
Primary
Human, Mouse
Antibody
IgG
SDS
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Product Certifications
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