LATS2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Catalog No.	Quantity
50-553-337	150 μL

Catalog No. 50-553-337 Supplier Proteintech Group Inc Supplier No. 202761AP150UL

Description

Rabbit Polyclonal Antibody

LATS2 has a calculated molecular mass of 120 kDa and an apparent molecular mass of 150 kDa. The antibody is specific to LATS2.

LATS2 is a serine/threonine kinase that serves as a negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. LATS2 acts as a tumor supressor which plays a critical role in centrosome duplication, maintece of mitotic fidelity and genomic stability. It negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity.

Specifications

• Antigen: LATS2
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.27 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: LATS2
• Gene Accession No.: Q7TSJ6, Q9NRM7
• Gene Alias: KPM, LATS2, Warts like kinase
• Gene Symbols: Lats2
• Host Species: Rabbit
• Immunogen: Peptide
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 26524, 50523
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG