Invitrogen™ LAX1 Polyclonal Antibody

Catalog No.	Quantity
PIPA588428	100 μL

Catalog No. PIPA588428 Supplier Invitrogen™ Supplier No. PA588428

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MPLLTLPQTR QRAKNIYDIL PWRQEDLGRH ESRSMRIFST ESLLSRNSES PEHVPSQAGN AFQEHTAHIH ATEYAVGIYD NAMVPQMCGN LTPSAHCINV RASRDCASIS SEDSHDYVNV PTAEEIAETL ASTKSPSRNL FVLPSTQKLE FTEERDEGCG DAGDCTSLYS PGAEDSDSLS NGEGSSQISN DYVNMTGLDL SAIQERQLWV AFQCCRDYEN VPAADPSGSQ QQAEKDVPSS NIGHVEDKTD DPGTHVQCVK RTFLASGDYA DFQPFTQSED SQMKHREEMS NEDSSDYENV LTAKLGGRDS EQGPGTQLLP DE; Positive Samples: Raji, Mouse liver; Cellular Location: Cell membrane, Single-pass type III membrane protein.

Lymphocyte activation gene 1 (LAX1) is located on chromosome 2p16.1 and encodes an immunoregulatory protein that is expressed primarily on lymphocytes, including T cells, B cells, and other immune cells. LAX1 functions as a negative regulator of lymphocyte activation and signaling, playing a crucial role in maintaining immune homeostasis by attenuating excessive immune responses. It acts by modulating signaling pathways that are initiated through surface receptors on lymphocytes, thereby influencing lymphocyte proliferation, cytokine production, and cellular responses during immune activation. Dysregulation of LAX1 expression or function can lead to autoimmune diseases due to impaired control of immune activation. Research into LAX1 focuses on its potential for therapeutic modulation in autoimmune disorders and its role in balancing immune responses, which is essential for maintaining health and preventing pathogenic immune conditions.

Specifications

• Antigen: LAX1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.39 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Lax1
• Gene Accession No.: Q8BHB3, Q8IWV1
• Gene Alias: A530029E09; E430019B13Rik; LAT-like membrane associated protein; LAX; LAX1; Linker for activation of X cells; lymphocyte transmembrane adapter 1; lymphocyte transmembrane adaptor 1; membrane-associated adapter protein LAX
• Gene Symbols: Lax1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 77-398 of human LAX1 (NP_0602432).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 240754, 54900
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG