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Invitrogen™ Layilin Monoclonal Antibody (328024)
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Catalog No. PIMA524054
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100 μg
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Catalog No. Quantity
PIMA524054 100 μg
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Catalog No. PIMA524054 Supplier Invitrogen™ Supplier No. MA524054
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Description

Mouse Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

Layilin is a cell surface receptor encoded by the LAYN gene, known for its involvement in cell adhesion and motility processes. It is a member of the C-type lectin-like domain protein family and plays a crucial role in mediating interactions with the extracellular matrix. Layilin is associated with cytoskeletal reorganization, impacting cellular processes such as shape change, migration, and stabilization of cell-matrix contacts. It has been shown to interact with other proteins like talin, contributing to the linkage between the cell membrane and the actin cytoskeleton, which is vital for maintaining cell structure and facilitating movement. Layilin's role in cell adhesion and motility makes it significant in developmental processes and wound healing. Additionally, dysregulation of layilin expression has been implicated in cancer metastasis, where altered adhesive properties and increased motility contribute to tumor progression and dissemination. Research is ongoing to explore the detailed mechanisms of layilin's function and its potential as a target for therapeutic intervention in diseases characterized by abnormal cell migration and adhesion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Layilin
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 328024
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene LAYN
Gene Accession No. Q6UX15, Q8C351
Gene Alias E030012M19Rik; FLJ30977; FLJ31092; Gm511; layilin; LAYN; LYAN; RGD1564444; UNQ208/PRO234
Gene Symbols LAYN
Host Species Mouse
Immunogen Mouse myeloma cell line NS0-derived recombinant human Layilin Ala22-Glu220.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 143903, 244864
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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