Invitrogen™ LC3A (Cleaved Gly120) Polyclonal Antibody

Catalog No.	Quantity
PIPA535196	400 μL

Catalog No. PIPA535196 Supplier Invitrogen™ Supplier No. PA535196

Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with bovine and rat based on sequence homology.

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

Specifications

• Antigen: LC3A (Cleaved Gly120)
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: MAP1LC3A
• Gene Accession No.: Q91VR7, Q9H492
• Gene Alias: 1010001H21Rik; 4922501H04Rik; ATG8E; Autophagy-related protein LC3 A; autophagy-related ubiquitin-like modifier LC3 A; LC3; LC3A; MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; MAP1ALC3; MAP1BLC3; MAP1LC3A; microtubule associated protein 1 light chain 3 alpha; Microtubule-associated protein 1 light chain; microtubule-associated protein 1 light chain 3 alpha; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3A
• Gene Symbols: MAP1LC3A
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 89-120 amino acids from human Cleaved LC3A or LC3B.
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 66734, 84557
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG