Invitrogen™ LDB3 Polyclonal Antibody

Catalog No.	Quantity
PIPA530434	100 μL

Catalog No. PIPA530434 Supplier Invitrogen™ Supplier No. PA530434

Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, RD, mouse muscle, rat muscle. Predicted reactivity: Mouse (97%), Rat (97%), Chicken (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains.

Specifications

• Antigen: LDB3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene: LDB3
• Gene Accession No.: O75112, Q9JKS4
• Gene Alias: AW742271; cardiomyopathy, dilated 1C (autosomal dominant); CMD1C; CMH24; CMPD3; cypher; FLJ35865; HGNC:15710; KIAA01613; KIAA0613; LDB3; LDB3Z1; LDB3Z4; LIM domain binding 3; LIM domain-binding protein 3; LVNC3; MFM4; ORACLE; oracle protein; PDLIM6; PDZ and LIM domain 6; PDZ-LIM domain protein; protein cypher; Protein oracle; RGD1564875; ZASP; Z-band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif protein
• Gene Symbols: LDB3
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human LDB3. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11155, 24131, 498587
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG