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  5. Tocris Bioscience™ LDC 000067

Tocris Bioscience™ LDC 000067

Catalog No. 67525
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25 mg
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Catalog No. Quantity
67-525 5 mg
67-522-5 25 mg
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Catalog No. 67-525 Supplier Tocris Bioscience™ Supplier No. 6752/5

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

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Description

Potent and selective CDK9 inhibitor (IC50 = 44 nM at CDK9-cyclin T1)

LDC 000067 is a potent and selective CDK9 inhibitor (IC50 = 44 nM at CDK9-cyclin T1). Inhibits other CDKs in the micromolar range (IC50 values are 2.4, 5.5, 9.2, >10 and >10 μM for CDK2-cyclin A, CDK1-cyclin B1, CDK4-cyclin D1, CDK6-cyclin D3 and CDK7-cyclin H-MAT1, respectively). Inhibits P-TEFb-dependent in vitro transcription. Induces apoptosis in vitro and in vivo in combination with BI 894999.

Specifications

Chemical Name or Material 3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide
CAS 1073485-20-7
Quantity 5 mg
Molecular Formula C18H18N4O3S
Formula Weight 370.43
Purity 98%
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