LDHA Mouse anti-Human, Clone: OTI5G10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500558

Catalog No. 50-165-9628

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84-89% sequence similarities and 69-75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers.

Specifications

• Antigen: LDHA
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: LDHA
• Gene Alias: GSD11, HEL-S-133P, LDHM, PIG19
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3939
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: OTI5G10
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P00338
• Gene Symbols: LDHA
• Immunogen: Full length human recombit protein of human LDHA produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1