Invitrogen™ LDHA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA517183

Catalog No. PIPA517183

Description

It is not recommended to aliquot this antibody.

Lactate dehydrogenase (LDH) is the enzyme in the glycolytic pathway that converts pyruvate to lactate with concomitant interconversion of NADH and NAD+. In mammals, the enzyme is encoded by three genes: LDHA (M or muscle form), LDHB (H or heart form), and LDHC (X or testis form). The three human LDHs have 84-89% sequence similarities and 69-75% amino acid identities. There are five different LDH isoenzymes based on the proportion of M and H chains existing in the LDH tetrameric structure. The LDHA is hypoxia inducible and its expression is directly controlled by the transcriptional activity of the hypoxia inducible factor 1a (HIF1a). LDHB is also known to be upregulated in many cancers. Mutations in the LDHA gene can lead to Glycogen storage disease 11 (GSD11).

Specifications

• Antigen: LDHA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LDHA
• Gene Alias: Cell proliferation-inducing gene 19 protein; epididymis secretory sperm binding protein Li 133P; GSD11; HEL-S-133P; l7R2; Lactate Dehydrogenase; lactate dehydrogenase 1, A chain; lactate dehydrogenase 3, C chain, sperm specific; lactate dehydrogenase A; lactate dehydrogenase A4; lactate dehydrogenase A-like; lactate dehydrogenase C; lactate dehydrogenase C variant 3; lactate dehydrogenase M; lactate dehydrogenase-A; lactate dehydrogenase-M; lactate dehydrogenase-M (EC 1.1.1.27); Lactic Dehydrogenase; LDH; LDH muscle subunit; LDH testis subunit; Ldh1; Ldh-1; Ldh3; Ldha; LDH-A; ldha protein; ldha1; LDH-A4 muscle-specific isozyme; glycolytic enzyme; Ldhc; LDH-C; Ldhm; LDH-M; LDH-X; L-lactate dehydrogenase; L-lactate dehydrogenase A chain; L-lactate dehydrogenase C chain; M-LDH; OTTHUMP00000165206; PIG19; proliferation-inducing gene 19; renal carcinoma antigen NY-REN-59
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16828, 24533, 29634, 3939
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 18 μg/mL
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene Accession No.: P00338, P04642, P06151, P19629
• Gene Symbols: LDHA
• Immunogen: Synthetic peptide corresponding to the sequence of human LDHA.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG