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Invitrogen™ LDL receptor Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5117365
Description
Centrifuge briefly prior to opening.
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
Specifications
LDL receptor | |
Polyclonal | |
Unconjugated | |
LDLR | |
FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
3949 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
2.03 mg/mL | |
PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
P01130 | |
LDLR | |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of Human LDL Receptor. The exact sequence is proprietary. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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