LDL receptor Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0455	100 μL

Catalog No. 50-198-0455 Supplier Bioss Supplier No. BS0705R

Description

Rabbit Polyclonal Antibody

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

Specifications

• Antigen: LDL receptor
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: LDLR
• Gene Accession No.: P01130
• Gene Alias: FH; FHC; Hlb301; LDL receptor; LDLCQ2; Ldlr; LDLRA; low density lipoprotein receptor; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
• Gene Symbols: LDLR
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human LDL-R.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3949
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG