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Invitrogen™ LDLR Monoclonal Antibody (02)
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Catalog No. PIMA530636
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100 μL
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PIMA530636 100 μL
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Catalog No. PIMA530636 Supplier Invitrogen™ Supplier No. MA530636
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Description

Mouse Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human LDLR/LDL R/LDL Receptor.

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LDLR
Applications ELISA
Classification Monoclonal
Clone 02
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene LDLR
Gene Accession No. P01130
Gene Alias FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Gene Symbols LDLR
Host Species Mouse
Immunogen Recombinant Human LDLR/LDL R/LDL Receptor Protein (Met1-Arg788).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3949
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
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