LDLR Mouse anti-Human, Clone:7H5B11, Abnova™

Catalog No.	Quantity
89-333-177	100 μg

Catalog No. 89-333-177 Supplier Abnova Corporation Supplier No. MAB16685

Description

Mouse monoclonal antibody raised against recombinant human LDLR.

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq]

Specifications

• Antigen: LDLR
• Applications: ELISA, Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: 7H5B11
• Conjugate: Unconjugated
• Description: low density lipoprotein receptor
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunohistochemistry
  Immunocytochemistry
  Flow Cytometry (1:200-1:400)
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: LDLR
• Gene Alias: FH, FHC
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acid 22-150 of human LDLR from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 3949
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1