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Invitrogen™ LDLR Recombinant Rabbit Monoclonal Antibody (032), FITC
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Catalog No. PIMA540965
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100 Tests
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PIMA540965 100 Tests
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Catalog No. PIMA540965 Supplier Invitrogen™ Supplier No. MA540965
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Description

Rabbit Recombinant Monoclonal Antibody

May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LDLR
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone 032
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 0.5% BSA and 0.03% ProClin 300
Gene LDLR
Gene Accession No. P35951
Gene Alias FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
Gene Symbols LDLR
Host Species Rabbit
Immunogen Recombinant Mouse LDLR/LDL Receptor protein.
Purification Method Protein A
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16835
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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