Invitrogen™ LDLR Recombinant Rabbit Monoclonal Antibody (032), PerCP

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA540964

Catalog No. PIMA540964

Description

May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

Specifications

• Antigen: LDLR
• Classification: Recombinant Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.5% BSA and 0.03% ProClin 300
• Gene Accession No.: P35951
• Gene Symbols: LDLR
• Immunogen: Recombinant Mouse LDLR/LDL Receptor protein.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry
• Clone: 032
• Conjugate: PerCP
• Gene: LDLR
• Gene Alias: FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16835
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid