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Invitrogen™ LDLRAD4 Polyclonal Antibody
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Catalog No. PIPA565879
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100 μL
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PIPA565879 100 μL
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Catalog No. PIPA565879 Supplier Invitrogen™ Supplier No. PA565879
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HYKVSTRSFIN RPNQSRRRED GLPQEGCLWP SDSAAPRLGA SEIMHAPRSR DRFTAPSFIQ RDRFSRFQ Highest antigen sequence identity to the following orthologs - mouse 81%, rat 81%.

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LDLRAD4
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene LDLRAD4
Gene Accession No. O15165
Gene Alias 8230401C20Rik; A430083H02; A430108L08Rik; C18orf1; clone 22; D18Ertd653e; D330030L18Rik; Ldlrad4; low density lipoprotein receptor class A domain containing 4; low-density lipoprotein receptor class A domain-containing protein 4; uncharacterized protein C18orf1 homolog
Gene Symbols LDLRAD4
Host Species Rabbit
Immunogen Recombinant Human LDLRAD4. Recombinant protein control fragment (Product #RP-103591).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 753
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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