Invitrogen™ LDLRAD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565879

Catalog No. PIPA565879

Description

Immunogen sequence: HYKVSTRSFIN RPNQSRRRED GLPQEGCLWP SDSAAPRLGA SEIMHAPRSR DRFTAPSFIQ RDRFSRFQ Highest antigen sequence identity to the following orthologs - mouse 81%, rat 81%.

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Specifications

• Antigen: LDLRAD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LDLRAD4
• Gene Alias: 8230401C20Rik; A430083H02; A430108L08Rik; C18orf1; clone 22; D18Ertd653e; D330030L18Rik; Ldlrad4; low density lipoprotein receptor class A domain containing 4; low-density lipoprotein receptor class A domain-containing protein 4; uncharacterized protein C18orf1 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 753
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O15165
• Gene Symbols: LDLRAD4
• Immunogen: Recombinant Human LDLRAD4. Recombinant protein control fragment (Product #RP-103591).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG