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Invitrogen™ LDLRAD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570568

Catalog No. PIPA570568


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Description

Description

This target displays homology in the following species: Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%.

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

LDLRAD4
Polyclonal
Unconjugated
LDLRAD4
8230401C20Rik; A430083H02; A430108L08Rik; C18orf1; clone 22; D18Ertd653e; D330030L18Rik; Ldlrad4; low density lipoprotein receptor class A domain containing 4; low-density lipoprotein receptor class A domain-containing protein 4; uncharacterized protein C18orf1 homolog
Rabbit
Affinity chromatography
RUO
753
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
O15165
LDLRAD4
synthetic peptide directed towards the middle region of human LDLRAD4 (aa 257-306).
100 μL
Primary
Human
Antibody
IgG
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