Invitrogen™ LDLRAD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570568

Catalog No. PIPA570568

Description

This target displays homology in the following species: Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%.

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Specifications

• Antigen: LDLRAD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LDLRAD4
• Gene Alias: 8230401C20Rik; A430083H02; A430108L08Rik; C18orf1; clone 22; D18Ertd653e; D330030L18Rik; Ldlrad4; low density lipoprotein receptor class A domain containing 4; low-density lipoprotein receptor class A domain-containing protein 4; uncharacterized protein C18orf1 homolog
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 753
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O15165
• Gene Symbols: LDLRAD4
• Immunogen: synthetic peptide directed towards the middle region of human LDLRAD4 (aa 257-306).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG