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Invitrogen™ LEMD2 Polyclonal Antibody
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Catalog No. PIPA553589
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100 μL
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PIPA553589 100 μL
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Catalog No. PIPA553589 Supplier Invitrogen™ Supplier No. PA553589
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EDNMKLLPVD CERKTDEFCQ AKQKAALLEL LHELYNFLAI QAGNFECGNP ENLKSKCIPV MEAQEYIANV TSSSSAKFEA ALTWILSSNK DVGIWLKGED QSELVTTVDK VVCLESAHP Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 90%.

The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LEMD2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene LEMD2
Gene Accession No. Q8NC56
Gene Alias BC026588; CTRCT42; dJ482C21.1; hLEM2; LEM domain containing 2; LEM domain-containing protein 2; Lem2; LEMD2; NET25; nuclear envelope constituent; Nuclear envelope transmembrane protein 25
Gene Symbols LEMD2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LEMD2. Recombinant protein control fragment (Product #RP-89512).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221496
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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