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Invitrogen™ LEMD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114066

Catalog No. PIPA5114066


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Description

Description

Immunogen sequence: QDMERYPYVG ILHVRDSLIP PQSRRRMKRV WDRAVEFLAS NESRIQTESH For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 89%.

The LEM (lamina-associated polypeptide-emerin-MAN1) domain is a motif shared by a group of lamin-interacting proteins of the inner nuclear membrane (INM) and nucleoplasm. One such protein, LEMD2 (LEM domain-containing protein 2), is a lamina-associated protein in the INM involved in nuclear structure organization, containing an N-terminal LEM motif, two transmembrane domains, and a MAN1-Src1p C-terminal (MSC) domain. LEMD2 is a truncated paralog of MAN1, lacking the MAN1-specific C-terminal RNA-recognition motif, but like MAN1 is required for myogenic differentiation. Mutations in LEMD2 are thought be among the possible causes of muscle disease.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

LEMD2
Polyclonal
Unconjugated
LEMD2
BC026588; CTRCT42; dJ482C21.1; hLEM2; LEM domain containing 2; LEM domain-containing protein 2; Lem2; LEMD2; NET25; nuclear envelope constituent; Nuclear envelope transmembrane protein 25
Rabbit
Affinity chromatography
RUO
221496
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Q8NC56
LEMD2
Synthetic peptide directed towards the middle region of human LEMD2.
100 μL
Primary
Human
Antibody
IgG
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