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Invitrogen™ LETMD1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA567341
Description
Immunogen sequence: FPRQLLIRHFW TPKQQTDFLD IYHAFRKQSH PEIISYLEKV IPLISDAGLR WRLTDLCTKI QRG Highest antigen sequence identity to the following orthologs - mouse 59%, rat 66%.
HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.
Specifications
LETMD1 | |
Polyclonal | |
Unconjugated | |
LETMD1 | |
1110019O13Rik; AI593524; BB130465; BB235638; Cervical cancer 1 proto-oncogene protein p40; cervical cancer proto-oncogene 2 protein; Cervical cancer receptor; HCCR1; HCCR-1; HCCR-2; HCRR-2; LETM1 domain containing 1; LETM1 domain-containing protein 1; LETMD1; MCC-32; Mccr; regulator of TP53; RGD1310591 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
25875 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q6P1Q0 | |
LETMD1 | |
Recombinant Human LETMD1. Recombinant protein control fragment (Product #RP-107990). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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