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Invitrogen™ LETMD1 Polyclonal Antibody
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Catalog No. PIPA596069
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100 μL
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PIPA596069 100 μL
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Catalog No. PIPA596069 Supplier Invitrogen™ Supplier No. PA596069
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FPRQLLIRHF WTPKQQTDFL DIYHAFRKQS HPEIISYLEK VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS NHPLGMNQLQ ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL LSTNYLGTRR; Positive Samples: MCF7, Mouse liver; Cellular Location: Mitochondrion outer membrane, Single-pass membrane protein.

HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LETMD1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.29 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene LETMD1
Gene Accession No. Q6P1Q0, Q924L1
Gene Alias 1110019O13Rik; AI593524; BB130465; BB235638; Cervical cancer 1 proto-oncogene protein p40; cervical cancer proto-oncogene 2 protein; Cervical cancer receptor; HCCR1; HCCR-1; HCCR-2; HCRR-2; LETM1 domain containing 1; LETM1 domain-containing protein 1; LETMD1; MCC-32; Mccr; regulator of TP53; RGD1310591
Gene Symbols LETMD1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 161-360 of human LETMD1 (NP_0562313).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25875, 681352, 68614
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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