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Invitrogen™ LETMD1 Polyclonal Antibody
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Catalog No. PIPA5104399
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PIPA5104399 100 μL
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Catalog No. PIPA5104399 Supplier Invitrogen™ Supplier No. PA5104399
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total LETMD1.

HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LETMD1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LETMD1
Gene Accession No. Q6P1Q0, Q924L1
Gene Alias 1110019O13Rik; AI593524; BB130465; BB235638; Cervical cancer 1 proto-oncogene protein p40; cervical cancer proto-oncogene 2 protein; Cervical cancer receptor; HCCR1; HCCR-1; HCCR-2; HCRR-2; LETM1 domain containing 1; LETM1 domain-containing protein 1; LETMD1; MCC-32; Mccr; regulator of TP53; RGD1310591
Gene Symbols LETMD1
Host Species Rabbit
Immunogen A synthesized peptide derived from human LETMD1(Accession Q6P1Q0), corresponding to amino acid residues T19-G69.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25875, 681352, 68614
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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