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Invitrogen™ LETMD1 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104399

Catalog No. PIPA5104399


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Description

Description

Antibody detects endogenous levels of total LETMD1.

HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360 amino acid single-pass membrane protein that is expressed in the kidney, liver, skeletal muscle, heart and brain. It is suggested that HCCR-1 may be involved in tumorigenesis and may function as a negative regulator of the p53 tumor suppressor. Overexpression of HCCR-1 may cause mitochondrial dysfunction that can lead to UVC or staurosporine-induced apoptosis resistance and progression of tumor formation. HCCR-1 is considered a candidate biomarker for breast cancer. Various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix have high HCCR-1. Six isoforms exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

LETMD1
Polyclonal
Unconjugated
LETMD1
1110019O13Rik; AI593524; BB130465; BB235638; Cervical cancer 1 proto-oncogene protein p40; cervical cancer proto-oncogene 2 protein; Cervical cancer receptor; HCCR1; HCCR-1; HCCR-2; HCRR-2; LETM1 domain containing 1; LETM1 domain-containing protein 1; LETMD1; MCC-32; Mccr; regulator of TP53; RGD1310591
Rabbit
Affinity chromatography
RUO
25875, 681352, 68614
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q6P1Q0, Q924L1
LETMD1
A synthesized peptide derived from human LETMD1(Accession Q6P1Q0), corresponding to amino acid residues T19-G69.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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