Invitrogen™ Levo-alpha-Acetylmethadol Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA175235

Catalog No. PIPA175235

Description

Working Concentration: 1/32K. Sensitivity: 10 ng/mL LAAM produces 80% inhibition in a competitive ELISA employing LevoAlphaAcetylmethadol (LAAM) polyclonal antibody.

Levomethadyl Acetate is only found in individuals that have used or taken this drug. It is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. [PubChem]Opiate receptors (Mu, Kappa, Delta) are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Levomethadyl acetate effectively opens calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist), resulting in hyperpolarization and reduced neuronal excitability. [National Center for Biotechnology Information. PubChem Compound Database; CID=15130].

Specifications

• Antigen: Levo-alpha-Acetylmethadol
• Classification: Polyclonal
• Formulation: PBS with 0.09% sodium azide; pH 7.3
• Host Species: Sheep
• Purification Method: Purified
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA
• Conjugate: Unconjugated
• Gene Alias: 1-alpha-Acetylmethadol; C23H31NO2; LAAM; Levacetylmethadol; Levomethadyl; Orlaam
• Immunogen: LAAM(p)-BSA.
• Quantity: 1 mg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov