Invitrogen™ LFG Monoclonal Antibody (2C2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA521391

Catalog No. PIMA521391

Description

Peptide Sequence: MTQGKLSVAN KAPGTEGQQQ VHGEKKEAPA VPSAPPSYEE ATSGEGMKAG AFPPAPTAVP LHPSWAYVDP SSSSSYDNGF PTGDHELFTT FSWDDQKVRR VFVRKVYTIL LIQLLVTLAV VALFTFCDPV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTVFTLSMA YLTGMLSSYY NTTSVLLCLG ITALVCLSVT VFSFQTKFDF TSCQGVLFVL LMTLFFSGLI LAILLPFQYV PWLHAVYAAL GAGVFTLFLA LDTQLLMGNR RHSLSPEEYI FGALNIYLDI IYIFTFFLQL FGTNRE.

LFG, a seven transmembrane spanning protein, is a recently identified member of a family whose members can inhibit apoptotic cell death induced by Fas receptor. LFG is a human homolog of rat NMP35 and consists of a conserved transmembrane domain and a small cytoplasmic domain. Reports have shown that LFG protects the cell from Fas-mediated neuronal cell death in a novel way. LFG binds to Fas receptor but doesn't have any effect in reducing Fas expression or decreasing the ability of FADD binding to the receptor. Furthermore, LFG doesn't protect the cells from TNF-alpha mediated cell death process. Although LFG is ubiquitously expressed, Northern blot analysis detected an increased expression in hippocampus and other neural tissues, suggesting a protective role in neurodegenerative diseases.

Specifications

• Antigen: LFG
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9BWQ8
• Gene Symbols: FAIM2
• Immunogen: FAIM2 (AAH00051, 1 a.a. ~ 316 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 2C2
• Conjugate: Unconjugated
• Gene: FAIM2
• Gene Alias: 2900002L20Rik; FAIM2; Fas apoptotic inhibitory molecule 2; fas apoptotic inhibitory molecule 2; protein lifeguard 2; Kiaa0950; Lfg; LFG2; lifeguard; neural membrane protein 35; NGP35; NMP25; Nmp35; protein lifeguard; protein lifeguard 2; TMBIM2; transmembrane BAX inhibitor motif-containing protein 2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23017
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid