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Invitrogen™ LGI1 Monoclonal Antibody (N283/7), APC
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Catalog No. PIMA545677
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100 μg
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PIMA545677 100 μg
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Catalog No. PIMA545677 Supplier Invitrogen™ Supplier No. MA545677
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Description

Mouse Monoclonal Antibody

Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4. 1 μg/mL of MA5-45677 was sufficient for detection of LGI1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 60kDa. This antibody was formerly sold as clone S283-7.

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LGI1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N283/7
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
Gene LGI1
Gene Accession No. O95970, Q8K4Y5, Q9JIA1
Gene Alias ADLTE; ADPAEF; ADPEAF; BB130740; EPITEMPIN; Epitempin 1; Epitempin-1; EPT; ETL1; IB1099; leucine rich glioma inactivated 1; leucine-rich glioma inactivated 1; leucine-rich glioma-inactivated protein 1; leucine-rich repeat LGI family, member 1; leucine-rich, glioma inactivated 1; LGI1; OTTHUMP00000020121; OTTHUMP00000020122; UNQ775/PRO1569
Gene Symbols LGI1
Host Species Mouse
Immunogen Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 252892, 56839, 9211
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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