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Invitrogen™ LGI1 Monoclonal Antibody (N283/7), PerCP

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545679

Catalog No. PIMA545679


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Description

Description

Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4. 1 μg/mL of MA5-45679 was sufficient for detection of LGI1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 60kDa. This antibody was formerly sold as clone S283-7.

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

LGI1
Monoclonal
1 mg/mL
2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
O95970, Q8K4Y5, Q9JIA1
LGI1
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG2a
Immunohistochemistry, Western Blot, Immunocytochemistry
N283/7
PerCP
LGI1
ADLTE; ADPAEF; ADPEAF; BB130740; EPITEMPIN; Epitempin 1; Epitempin-1; EPT; ETL1; IB1099; leucine rich glioma inactivated 1; leucine-rich glioma inactivated 1; leucine-rich glioma-inactivated protein 1; leucine-rich repeat LGI family, member 1; leucine-rich, glioma inactivated 1; LGI1; OTTHUMP00000020121; OTTHUMP00000020122; UNQ775/PRO1569
Mouse
Protein G
RUO
252892, 56839, 9211
4°C
Liquid
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