Learn More
Invitrogen™ LGI1 Monoclonal Antibody (N283/7), PerCP
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA545679
Description
Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4. 1 μg/mL of MA5-45679 was sufficient for detection of LGI1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 60kDa. This antibody was formerly sold as clone S283-7.
The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist.
Specifications
LGI1 | |
Monoclonal | |
1 mg/mL | |
2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4 | |
O95970, Q8K4Y5, Q9JIA1 | |
LGI1 | |
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG2a |
Immunohistochemistry, Western Blot, Immunocytochemistry | |
N283/7 | |
PerCP | |
LGI1 | |
ADLTE; ADPAEF; ADPEAF; BB130740; EPITEMPIN; Epitempin 1; Epitempin-1; EPT; ETL1; IB1099; leucine rich glioma inactivated 1; leucine-rich glioma inactivated 1; leucine-rich glioma-inactivated protein 1; leucine-rich repeat LGI family, member 1; leucine-rich, glioma inactivated 1; LGI1; OTTHUMP00000020121; OTTHUMP00000020122; UNQ775/PRO1569 | |
Mouse | |
Protein G | |
RUO | |
252892, 56839, 9211 | |
4°C | |
Liquid |
Safety and Handling
Your input is important to us. Please complete this form to provide feedback related to the content on this product.