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Invitrogen™ LGI1 Polyclonal Antibody
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Catalog No. PIPA528291
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100 μL
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PIPA528291 100 μL
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Catalog No. PIPA528291 Supplier Invitrogen™ Supplier No. PA528291
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: U87-MG, SK-N-SH, SK-N-AS, rat brain, 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (95%), Rat (95%), Chicken (87%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen LGI1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene LGI1
Gene Accession No. O95970, Q8K4Y5
Gene Alias ADLTE; ADPAEF; ADPEAF; BB130740; EPITEMPIN; Epitempin 1; Epitempin-1; EPT; ETL1; IB1099; leucine rich glioma inactivated 1; leucine-rich glioma inactivated 1; leucine-rich glioma-inactivated protein 1; leucine-rich repeat LGI family, member 1; leucine-rich, glioma inactivated 1; LGI1; OTTHUMP00000020121; OTTHUMP00000020122; UNQ775/PRO1569
Gene Symbols LGI1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human LGI1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 252892, 9211
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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